Dynamic Light Scattering Instrument

All laboratories involved in biomolecular characterization require a complete understanding of how their proteins and other biomolecules function in solution. Stability, conformation, aggregation and complex formation are all important issues facing a wide variety of biomolecular research and development organizations. The Viscotek DLS instrument is an essential tool that can provide this information in a fast, accurate and user-friendly manner.

The new Viscotek Model 802 DLS is a state-of-the-art dynamic light scattering instrument matched to a user-friendly software system to generate the most sensitive and accurate performance available. It is a completely new instrument incorporating the advantageous Single Mode Fibre (SMF) technology (exclusive to Viscotek) and more than 15 years experience of design, production, application and support of dynamic light scattering instrumentation and software.

The Viscotek DLS is the fast and accurate way to characterize biomolecules in solution. Requiring only a small volume of sample (10μl), which is recoverable. The sample is introduced into the sample cell which is placed in the temperature controlled cell holder. The software controlled instrument then makes the measurement and the results are displayed in seconds. A complete analysis from start to finish can be accomplished in minutes.

The Viscotek DLS serves a broad range of applications including discovery, development

and delivery, some examples are:

• Screen for aggregation prior to protein crystallization

• Monitor changes in size and aggregation as a function of varying solution conditions

• Protein conformation analysis

• Study protein-protein interactions in solution

• Characterize newly purified proteins for homogeneity, size and thermal stability

• Screen biotherapeutics for self-association over a broad range of solution conditions

• Measure the stability and size of lipids, conjugates and other drug delivery particles

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